主持十余项国家基金项目的研究,包括国家自然科学基金重点项目和国家科技部重大科学计划课题等,主要研究妊娠疾病和胎
儿发育,论文在Endocrine Reviews、Diabetes、Science Signaling、FASEB J、Clinical Science 及JCEM等杂志,主编《胎盘内
分泌的基础与临床》专著。
研究方向:
生殖内分泌
研究内容:
采用细胞生物学和分子生物学方法研究胎盘激素和因子的表达调控机制,并研究这些胎盘激素和因子对妊娠和胎儿发育的影
响。
代表性论文:
1. 卢 Y, 周 Q, 卢 JW, 王 WS, 孙 K*.STAT3 参与人羊膜成纤维细胞中 SAA1 和皮质醇对 11 b-HSD1 的协同诱导。美国生
殖免疫学杂志 2019, 82(2):e13150.
2. Lu JW, Wang WS, Myatt L, Sun K*. 前列腺素EP4受体的激活减弱了诱导 人 EP2 受体激活对环氧合酶-2 的表达 羊膜成
纤维细胞:对分娩的影响。法塞布 J 2019, 33(7):8148-8160.
3. Lu Y, Wang WS, Lin YK, Lu JW, Li WJ, Zhang CY, Sun K*. SAA1 增强人皮质醇诱导的 SAA1 转录 羊膜。分子内分
泌杂志 2019,62:149-158.
4. 王丽, 王伟, 王永华, 卢俊, 陆勇, 张 CY, 李伟杰, 孙 K*, 英 H*.皮质醇在人体中剧烈诱导 MMP-7 羊膜:对分娩时
胎膜破裂的影响。FASEB杂志 2019,33(2):2770-2781.
5. 王伟*, 李伟杰, 王永伟, 王吕, 米永宝, 卢杰, 卢勇, 张CY, 孙K*.血清淀粉样蛋白 A1 参与胎膜破裂 通过诱导胶原
蛋白 I 降解。临床科学 2019, 133: 515-530.
6. 王永伟, 王伟*, 王丽, 宝年, 卢俊, 卢勇, 张 CY, 李伟杰, 孙 K*, 英 H*.血清细胞外基质重塑作用 人羊膜中的淀
粉样蛋白 A1:对胎膜的影响 破裂。美国生殖免疫学杂志 2019,81(1):e13053。
8. 陈 C, 张 JW, 夏 HW, 张 HX, 贝特兰 AP, 张 L, 华 XL, Feng LP, Chen D, Sun K, Guo CM, Qi HB, Duan
T, Zhang J. 早产流行病学 2015年和2016年的中国:一项全国性调查。 柳叶刀 2018, 392, S73.
9. 张 CY, 马 J, 王 WS, 孙 Y, 孙 K*.赖氨酰氧化酶阻断可改善多囊患者的无排卵 卵巢综合征。嗡嗡声 2018,33(11):
2096-2106.
10. 王伟, 陈志杰, Myatt L, 孙 K*. 11β-HSD1在人胎膜中作为潜在的治疗靶点 用于早产。内分泌修订版 2018,39:241-
260。
11. 米YB, 王WS, 卢JW, Ying H, Sun K*.蛋白酶体介导的皮质醇对胶原蛋白III的降解 人羊膜成纤维细胞:对膜破裂的影
响。分子内分泌杂志 2018, 60 (2), 45-54.doi: 10.1530/JME-17-0215.
12. Lu JW, Wang WS, Mi YB, Zhang CY, Ying H, Wang LY, Wang YW, Myatt L, Sun K*. AKAP95介导的PKA核锚定
介导皮质醇诱导 PTGS2 在人羊膜成纤维细胞中的表达。科学信号 2017, 10(506).PII:EAAC6160。doi:
10.1126/scisignal.aac6160.
13. 张婷, 王伟, 刘春, 卢俊武, 孙K*. NF- 的作用kB/GATA3 在人羊膜中 IL-1β 抑制赖氨酰氧化酶 成纤维细胞。 免疫细胞
生物学 2017, 95:943-952.
14. 刘旭华, 左RJ*, 宝冉, 曲二十, 孙K*, 英华*. PDK4 的下调对于碳水化合物的转换至关重要 人胎盘滋养细胞合胞体化
过程中的分解代谢。科学代表 2017;7:8474 |DOI:10.1038/s41598-017-09163-8 (共对应 作者)。
15. 李尚, 翟俊宇, 刘建生, 洪闫, 赵伟秀, 爱民 赵康, 孙康, 杜彦志, 陈子江.BMAL1 促进滋养层迁移 和通过 SP1-
DNMT1/DAB2IP 通路侵袭复发性自发性 流产。Oncotarget.2017 https://doi.org/10.18632/oncotarget.20702。
16. 翟杰, 刘杰, 程旭, 李旭, 洪勇, 孙凯, 陈志杰, 杜勇, 李伟. 锌指基因217(ZNF217)促进卵巢过度刺激 通过调
节 E2 合成和抑制的综合征 (OHSS) 血小板反应蛋白-1 (TSP-1)。 科学代表2017年6月12日;7(1):3245.doi:
10.1038/s41598-017-03555-6.
17. 左RJ, 刘旭华, 王伟杰, 莹华, 孙K*. zeste 同源物 2 增强子的抑制作用 11β-羟基类固醇脱氢酶 2 型在人中的表达 胎
盘。生物化学杂志 2017, 292 (18):7578–7587.
18. Li WJ, Wang WS, Zuo RJ, Liu C, Shu Q, Ying H, Sun K*. Induction of pro-inflammatory genes by serum amyloid A1 in
human amnion fibroblasts. Sci Rep 2017; 7: 693. DOI:10.1038/s41598-017-00782-9.
19. Mi YB, Wang WS, Zhang CY, Liu C, Lu JW, Li WJ, Zuo RJ, Myatt L, Sun K*. Autophagic degradation of collagen 1A1 by
cortisol in human amnion fibroblasts. Endocrinology 2017; 158:1005–1014. (Editors’ choice with comments)
20. Wang WS, Liu C, Sun K*. Induction of amnion epithelial apoptosis by cortisol via tPA/Plasmin System. Endocrinology
2016; 157: 4487-4498.
21. Zhu QL, Zuo RJ, He YQ, Wang Y, Chen ZJ, Sun Y*, Sun K*. Local regeneration of cortisol by 11β-HSD1 contributes to
insulin resistance of the granulosa cells in PCOS. J Clin Endocrinol Metab 2016;101(5):2168-77.
22. Liu C, Guo C, Wang W, Zhu P, Li W, Mi Y, Myatt L, Sun K*. Inhibition of lysyl oxidase by cortisol regeneration in human
amnion: Implications for rupture of fetal membranes. Endocrinology 2016;157(10):4055-4065
23. Yang QL, Wang WS, Liu C, Wang Y*, Sun K*. Compartmentalized localization of 11β-HSD 1 and 2 at the feto-maternal
interface in the first trimester of human pregnancy. Placenta 2016; 46:63-71.
24. Yang QL, Wang WS, Liu C, Wang Y*, Sun K*. Effect of PFOS on glucocorticoid-induced changes in human first trimester
decidua. Reprod Toxicol 2016 Aug; 63:142-50.
25. Liu C, Zhu P, Wang WS, Li WJ, Shu Q, Chen ZJ, Myatt L, Sun K*. Inhibition of lysyl oxidase by prostaglandin E2 via
EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition. Mol Cell Endocrinol 2016; 424:118-127.
26. Wang WS, Guo CM, Zhu P, Lu JW, Li WJ, Liu C, Xie HL, Myatt L, Chen ZJ, Sun K*. Phosphorylation of STAT3 mediates the
induction of cyclooxygenase-2 by cortisol in the human amnion at parturition. Sci Signal, 2015; 8 (400): ra106. (Featured as
a cover article with focus comments in Sci Signal, Biol Reprod and Chemical & Engineering News )
27. Zhang N, Wang WS, Li WJ, Liu C, Chen Y, Yang QL, Wang Y*, Sun K*. Inhibition of 11β-HSD2 expression by triclosan via
induction of apoptosis in human placental syncytiotrophoblasts. J Clin Endocrinol Metab 2015; 100: E542–E549. (selected
as a translational highlight by JCEM)
28. Zhang N, Wang WS, Li WJ, Liu C, Wang Y*, Sun K*. Impairment of the endocrine function of human placental
syncytiotrophoblasts by perfluorooctane sulfonate via induction of apoptosis. Placenta 2015; 36: 575-580.
29. Shu Q, Li WJ, Li JN, Wang WS, Liu C, Sun K*. Cross-talk between cAMP and MAPK pathways in 11beta-HSD2 induction
by hCG in placental trophoblasts. PLoS ONE 2014 Sep 17;9(9):e107938. doi: 10.1371/journal.pone.0107938..
30. Guo CM, Wang WS, Liu C, Myatt L*, Sun K*. Induction of PGF2α synthesis by cortisol through GR dependent induction
of CBR1 in human amnion fibroblasts. Endocrinology 2014; 155(8):3017-3024.
31. Li XQ, Zhu P, Myatt L*, Sun K*. Roles of Glucocorticoids in Human Parturition: A Controversial Fact? Placenta 2014;
35:291-296. (invited review).
32. Wang WS, Liu C, Li WJ, Zhu P, Li JN, Sun K*. Involvement of CRH and hCG in the induction of aromatase by cortisol in
human placental syncytiotrophoblasts. Placenta 2014; 35(1):30-36. (Featured in MDLinx)
33. Wu XH, Huang XW, Qun L, Li YN, Wang Y, Liu C, Ma YY, Liu QM, Sun K, Qian F, Jin L, Wang JC. Two functional loci in the
promoter of EPAS1 gene involved in high-altitude adaptation of Tibetans. Sci Rep 2014 Dec 12; 4:7465. doi: 10.1038/srep07465.
34. Guan H, Sun K, Yang K. The ERK1/2 Signaling Pathway Regulates 11beta-Hydroxysteroid Dehydrogenase Type 2
Expression in Human Trophoblast Cells Through a Transcriptional Mechanism. Bio Reprod 2013; 89(4), 92,1-7.
35. Li JN, Wang WS, Liu C, Wang WH, Li WJ, Shu Q, Chen ZJ,Sun K*. Critical role of histone acetylation by p300 in human
placental 11β-HSD2 Expression. J Clin Endocrinol Metab 2013; 98:E1189-E1197. (Selected as a translational highlight by
JCEM)
36. Guo CM, Li C, Myatt L, Nathanielsz, PW, Sun K*. Sexually dimorphic effects of maternal nutrient reduction on expression
of genes regulating cortisol metabolism in fetal baboon adipose and liver tissues Diabetes 2013; 62(4):1175-1185.
(recommended by Faculty 1000)
37. Wang WS, Li JN, Ge YC, Li WJ, Shu Q, Guan H, Yang K, Myatt L, Sun K*. Cortisol induces aromatase expression in
human placental syncytiotrophoblasts through the cAMP/Sp1 pathway. Endocrinology 2012; 153:2012-2022.
38. Wang WH, Guo CM, Li WJ, Li JN, Wang WS, Myatt L, Sun K*. Involvement of GR and p300 in the induction of H6PD by
cortisol in human amnion fibroblasts. Endocrinology 2012; 153:5993-6002.
39. Guo CM, Kasaraneni N, Sun K*, Myatt L*. Cross Talk between PKC and CREB in the Induction of COX-2 by PGF2α in
Human Amnion Fibroblasts. Endocrinology. 2012; 153:4938-4945.
40. Li JN, Ge YC, Yang Z, Guo CM, Duan T, Myatt L, Guan H, Yang K, Sun K*. The Sp1 transcription factor is crucial for the
expression of 11beta-hydroxysteroid dehydrogenase type 2 in human placental trophoblasts. J Clin Endocrinol Metab 2011;
86: E899-907 (selected as a translational highlight by JCEM, Mol Endocrinol and Endocrinology).
41. Ge YC, Li JN, Ni XT, Guo CM, Wang WS, Duan T and Sun K*. Cross-talk between cAMP and p38 MAPK pathways in the
induction of leptin by hCG in human placental syncytiotrophoblasts. Reproduction 2011; 142: 369–375.
42.Guo CM, Li JN, Myatt L, Zhu XO, Sun K*. Induction of Gas contributes to the paradoxical stimulation of cytosolic phosph
olipase A2aexpression by cortisol in human amnion fibroblasts. Mol Endocrinol 2010; 24:1052-1061.
43.Guo CM, Ni XT, Zhu P, Li WJ, Zhu XO, Sun K*. Induction of progesterone receptor A form attenuates the induction of cyt
osolic phospholipase A2a expression by cortisol in human amnion fibroblasts. Reproduction 2010; 139:915-922.
44. Myatt L*, Sun K. Role of Fetal Membranes in signaling of fetal maturation and parturition. Int J Dev Biol 2010; 54:545-553
(invited review).
45. Guo CM, Zhu XO, Ni XT, Yang Z, Myatt L, Sun K*. Expression of progesterone receptor A form and its role in the interaction
of progesterone with cortisol on cyclooxygenase-2 expression in amnionic fibroblasts. J Clin Endocrinol Metab 2009; 94:5085-5
092. (selected as a translation highlight by Mol Endocrinol and featured in MDLinx).
46.Yang Z, Zhu P, Guo CM, Zhu XO, Sun K*. Expression of 11b-hydroxysteroid dehydrogenase type 1 in human fetal lung and
regulation of its expression by interleukin-1b and cortisol. J Clin Endocrinol Metab 2009; 94: 306-313.
47. Zhu XO, Yang Z, Guo CM, Ni XT, Li JN, Ge YC, Myatt L, Sun K*. Paradoxical stimulation of cyclooxygenase-2 expression by
glucocorticoids via a cyclic-AMP response element in human amnion fibroblasts. Mol Endocrinol 2009; 23:1839-1849.
48. Ni XT, Duan T, Yang Z, Guo CM, Li JN, Sun K*. Role of human chorionic gonadotropin in maintaining 11b-hydroxysteroid de
hydrogenase type 2 expression in human placental syncytiotrophoblasts. Placenta 2009; 30:1023-1028. (recommended by Faculty 1000)
51. Guo CM, Yang Z, Li WJ, Zhu P, Myatt L, Sun K*. Paradox of glucocorticoid-induced cytosolic phospholipase A2 mRNA expression involves glucocorticoid receptor binding to the promoter in human
amnion fibroblasts. Biol Reprod 2008; 78:193-197.
52. Shelby BD, LaMarca HL, McFerrin HE, Nelson NB, Lasky JA, Sun K, Myatt L, Offermann MK, Morris CA, Sullivan DE. Kaposi's sarcoma associated herpes virus G-protein coupled receptor activation of
cyclooxygenase-2 in vascular endothelial cells. Virol J 2007; 4:87-96.
53. Yang Z, Guo CM, Zhu P, Li WJ, Myatt L, Sun K*. Role of glucocorticoid receptor and C/EBPa in the feed-forward induction of 11b-hydroxysteroid dehydrogenase type 1 expression by cortisol in human
amnion fibroblasts. J Endocrinol 2007; 195:241-253.
54. Li WJ, Gao L, Wang Y, Duan T, Myatt L, Sun K*. Enhancement of Cortisol-Induced 11b-Hydroxysteroid dehydrogenase Type 1 Expression by Interleukin 1b in Cultured Human Chorionic Trophoblast
Cells. Endocrinology 2006; 147:2490-2495.
55. Sun K*, Brockman D, Campos B, Pitzer B, Myatt L. Induction of surfactant protein A expression by cortisol facilitates prostaglandin synthesis in human chorionic trophoblasts. J Clin Endocrinol Metab
2006; 91:4988-4994.
56. Sun K*, Qu XC, Gao L, Myatt L. Dexamethasone Fails to Inhibit the Induction of Cytosolic Phospholipase A2 expression by interleukin-1b in Cultured Human Amnion Fibroblasts. Placenta 2006; 27:164-
170.
57. Sooranna SR, Grigsby PL, Engineer N, Liang Z, Sun K, Myatt L, Johnson MR. Myometrial prostaglandin E2 synthetic enzyme mRNA expression: spatial and temporal variations with pregnancy and
labour. Mol Hum Reprod 2006; 12:625-631.
58. Wan SL, Hao RS, Sun K*. Repeated Maternal Dexamethasone Treatments in Late Gestation Increases 11b-Hydroxysteroid Dehydrogenase Type 1 Expression in the Hippocampus of the Newborn Rat.
Neurosci Lett 2005;382:96-101.
59. Sun K*, Ma RL, Cui XL, Campos B, Webster R, Brockman D, Myatt L. Glucocorticoids induce cytosolic phospholipase A2
and prostaglandin H synthase type 2 but not microsomal prostaglandin E synthase (PGES) and cytosolic PGES expression in
cultured primary human amnion cells. J Clin Endocrinol Metab 2003; 88:5564-5571.
60. Sun K*, Myatt L. Enhancement of glucocorticoid-induced 11b-Hydroxysteroid Dehydrogenase Type 1 Expression by pro-
inflammatory cytokines in the amnion fibroblasts. Endocrinology 2003; 144:5568-5577.
61. Sun K*, He P, Yang K. The intracrine induction of 11β-hydroxysteroid dehydrogenase type 1 expression by glucocorticoid
potentiates prostaglandin production in the human chorionic trophoblast. Biol Reprod 2002; 67:1450-1455.
62. Wan SL, Liao MY, Sun K*. Postnatal development of 11β-hydroxysteroid dehydrogenase type 1 in the rat hippocampus. J
Neurosci Res 2002; 69:681-686.
63. Qiu J, Wang P, Jing Q, Zhang W, Li X, Zhong Y, Sun K, Pei G, Chen YZ*. Rapid activation of ERK1/2 mitogen-activated
protein kinase by corticosterone in PC12 cells. Biochem Biophys Res Commun 2001; 287:1017-24.
64. Patel FA*, Sun K, Challis JRG. Local modulation by 11-beta hydroxysteroid dehydrogenase of glucocorticoid effects on
the activity of 15-hydroxyprostaglandin dehydrogenase in human chorion and placental trophoblast cells. J Clin Endocrinol
Metab 1999; 84:395-400. (commented by JCEM)
65. Sun K, Adamson L, Yang K, Challis JRG*. Interconversion of cortisol and cortisone by 11beta-hydroxysteroid
dehydrogenases type 1 and 2 in the perfused human placenta. Placenta 1999; 20:13-19.
66. Sun K*, Yang K, Challis JRG. Regulation of 11 beta-hydroxysteroid dehydrogenase type 2 by progesterone, estrogen and
cyclic AMP pathway in cultured placental syncytiotrophoblast. Biol Reprod 1998; 58: 1379-1384.
67. Sun K, Yang K, Challis JRG*. Glucocorticoid actions and metabolism in pregnancy: implications for placental function and
fetal cardiovascular activity. Placenta 1998; 19:353-360.
68. Sun K*, Yang K, Challis JRG. Differential expression of 11-beta hydroxysteroid dehydrogenase type 1 and 2 in human
placenta and fetal membranes. J Clin Endocrinol Metab 1997; 82:300-305.
69. Sun K*, Yang K, Challis JRG: Differential regulation of 11-beta hydroxysteroid dehydrogenase type 1 and 2 by nitric
oxide in cultured human placental syncytiotrophoblast and chorionic cell preparation. Endocrinology 1997; 138:4912-4920.
70. Sun K*, Robinson PJ. Inhibition of protein kinase A and protein kinase G by hydralazine but not by KRN2310 in vitro.
Acta Pharmacologica Sinica 1995; 16:276-280.
71. Sun K, Smith R, Robinson PJ*: Regulation of corticotrophin-releasing hormone release from human placental
syncytiotrophoblasts by KCl and sodium nitroprusside. J Clin Endocrinol Metab 1994; 79:519-524.
72. Sun K*, Lin BC, Wang CH, et al: Comparison of selective arginine vasopressin V1 and V2 receptor antagonists on burn
shock in the rat. Cardiovasc Res 1991; 25:265-269.
73. Sun K*, Gong A, Lin BC, et al: Effect of peripheral injection of arginine vasopressin and its antagonist on burn shock in
the rat. Neuropeptides 1990; 17:17-22.
74. Sun K*, Zhang C, Lin BC, et al: Possible involvement of beta-endorphin in the deteriorating effect of arginine
vasopressin on burn shock in rats. Circ Shock 1989; 29:167-174.
75. Lin BC, Sun K, Gao GC, et al: Neuropeptides and Burns. In: Advances in Burn edited by Sheng ZY and Zhu ZM,
International Academic Publishers, Beijing. P1-8, 1992.
76. He P, Sun K*. Effect of glucocorticoid on promoter of 11b-hydroxysteroid dehydrogenase I gene. Journal of Medical
Colleges of PLA 2003; 18:150-153.
77. Tang XL, Ni X, You ZD, He P, Hui N, Gu Q, Sun K. Estrogen inhibits corticotropin-releasing hormone production in
primary human placental cells. Journal of Medical Colleges of PLA 2003;18:183-185。
78. Gao GC, Lin BC, Sun K. The role of beta-endorphin in experimental burn shock. Adv Bio Sci 1989; 75:631-638.
81. 李召峰、万顺伦、曲宪成、孙刚*. 妊娠期过多糖皮质激素对胎儿肝脏11b-HSD1表达的印迹作用。第二军医大学学报
2005;26:61-64.郝如松、孙刚*. 甲状腺素对新生大鼠海马11b-HSD1表达的影响。第二军医大学学报 2004;25:1062-1065.
83. 金丹、刘彦、倪鑫、孙刚. 妊娠期血浆CRH与早产、贫血和肝功能损害的临床研究。国外医学妇幼保健分册 2003;14:1-
3.
85. 万顺伦、廖茂瑶、孙刚*:糖皮质激素代谢酶11b-羟基类固醇脱氢酶I型在新生大鼠脑内的分布与表达。 解剖学报 2003:
34:353-356.
86. 何平,孙刚*: 糖皮质激素受体和11b-HSD1在人绒毛膜滋养层细胞的共存与意义。中国应用生理学杂志 2003;19:291-
294.
87. 万顺伦、廖茂瑶、郝如松、李召峰、孙刚*. 大鼠海马神经元内11β-HSD1和GR的共存与意义。生理学报 2002;54:473-
478.
88. 宁洪艳、沙金燕、倪鑫、孙刚. 胎盘促肾上腺皮质激素释放激素水平与妊娠关系的研究。第二军医大学学报 2002;
23:316-317.
90. 万顺伦、孙刚*. 糖皮质激素代谢酶11β-羟基类固醇脱氢酶I型参与糖皮质激素对神经元的毒性作用。第二军医大学学报
2002;23:534-538.
92. 侯月、郝如松、万顺伦、倪鑫、孙刚*. 糖皮质激素对胎儿下丘脑-垂体-肾上腺皮质轴的印迹效应。生理科学进展 2002
;33:154-156.
100. 肖振祥、王伟忠、施善芬、陈辉、孙刚. 大鼠头端延髓腹外侧区NMDA受体在动脉压力感受器反射中的作用。第二军医大
学学报 2000;21:739-741.
102. 孙学军、孙刚、王成海等. MK-801对脑创伤大鼠部分脑区和垂体强啡肽A1-13含量的影响。放射免疫学杂志
1997;10:255-257.
104. 孙学军、孙刚、王成海等. 强啡肽A1-13对实验性颅脑伤后脑水肿的作用与机制研究。中华实验外科杂志 1996;13:143-
144.
106. 孙学军、王成海、黄爱军、孙刚等. 氯氨酮对颅脑损伤大鼠部分脑区和垂体强啡肽A1-13含量的影响。中华创伤杂志
1995;11:21.
108. 孙刚、王成海、路长林等. 精氨酸升压素对烫伤休克大鼠心功能的抑制作用及其机制。第二军医大学学报 1995;16:515-
519
113. 孙刚、王成海、宋朝佑、林葆成、朱鹤年. 大鼠烫伤休克晚期精氨酸加压素免疫活性物质的变化。放射免疫学杂志
1992;5:154-155.
115. 薛建中、方之扬、葛绳德、陈玉林、王成海、孙刚等. 烧伤病人血浆-内啡肽免疫活性物质含量的变化及其意义。中华整
形烧伤外科杂志 1991;7:253-256.
116. 孙刚、王成海、林葆成、朱鹤年. 第三脑室注射精氨酸加压素对烫伤休克大鼠的影响。中国应用生理学杂志 1989;5:389-
393.
117. 孙刚、林葆成、王成海、朱鹤年. 烫伤休克大鼠血浆及部分脑区精氨酸加压素样免疫活性物质的变化。第二军医大学学报
1989;10:333-335.